Lymphoepithelioma-like Gastric Carcinoma (LELGC): A Case Report and Review of Literature

Abstract

Lymphoepithelioma-like gastric carcinoma (LELGC),  is a rare type of gastric cancer characterized by a carcinoma with intense stromal lymphocytic infiltration. It is one of the histological patterns observed in patients with Epstein-Barr virus (EBV)-associated gastric carcinoma. According to the World Health Organisation classification of tumors of digestive sysytem 2010, LELGC is a rare type of tubular carcinoma. Although this entity is hard to be recognized in the biopsy specimens, pathologists and clinicians should acknowledge this subset of gastric cancer because it generally has a better prognosis than other forms of EBV-associated gastric carcinomas and conventional gastric carcinomas. This might be due to the fact that the patient's inflammatory response may prevent the spread of tumor through the gastric wall and to the lymph nodes or remote organs.⁽²¹⁾ In order to gain a detailed understanding of this rare disease, we reviewed the literature and report here a recent case of epithelioid gastric cancer in a 60 year old male patient presented in our Emergency Department.

Keywords: Lymphoepithelioma-like Gastric Carcinoma, gastric cancer , Ebstein-Barr virus, prognosis