Immunotherapeutic Potential of Plasmodium Against Cancer by Inducing Immunomodulation

Abstract

Cancer is one of the most death leading disease across the globe because of the unavailability of innocuous treatment strategy for cancer control so far but while having comparative study with malaria, it was found that there is some resemblance within the physiological conditions of the body as well as some antagonistic effects. Plasmodium is a parasitic microbe that is familiar for causing malaria within the animals and by thorough study, the immunotherapeutic potential of this organism was found against cancer as it consists of some tumor-associated antigens (TAAs) that favors the body in combating tumor by inducing immunomodulation and causing certain advantageous physiological changes.

Keywords: Chimeric Antigen Receptor, Genetically Attenuated Sporozoites, Glycosyl Phosphatidyl Inositol, Hepatocellular Carcinoma, Interdomain, Interferon, Lewis Lung Cancer, Pathogen-associated Molecular Patterns, Tumor-associated Antigens, Terminal deoxynucleotidyl Transferase-dUTP Nick End Labeling

DOI: 10.7176/ALST/70-03