Study the role of Estradiol and Luteinizing hormones in breast tumors incidence in the women in Al-Najaf Governorate- Iraq

Abstract

This study aims to illustration the role of some important risk factors which including age, age at menarche , menopausal status, the levels of estradiol(E2) and luteinizing hormones(LH) in the increasing breast tumors incidence by using 120 women, divided into three groups; control group including forty healthy women, benign group containing forty women with breast benign tumor and malignant group of forty women with malignant breast tumor, this last group subdivided into; malignant presurgery and malignant post surgery groups each one contain twenty women.    The results showed that benign breast tumors are  more common in women with interval age 31-40 years whereas malignant breast tumors were more common in women with interval age 41-50 years. Early age at menarche wasn’t significantly associated with increasing breast cancer incidence, contrariwise menopausal status which was significantly associated with increasing this disease .   The results revealed a significant elevation P? 0.05 in the levels of estradiol E₂, and Luteinizing hormones in the women with breast cancer before tumor excision and reduction in the levels of these hormones in the women after tumor excision indicating the role of these hormones in the initiation or promotion breast cancer.

In conclusion, this study revealed that breast cancer incidence increased in women in forties and fifties of age and increasing the levels of endogenous hormones such as Estradiol, and luteinizing hormones can increased risk of developing breast cancer especially in postmenopausal women.

Key word : Brest cancer  , Risk factor ,  Estradiol(E2) ,  luteinizing hormones