Preparation, Characterization, and Antibacterial Properties of mixed ligand Complexes of L-leucine and Sulfamethoxazole with Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II) ions

Raheem Taher Mahdi, Taghreed H. Al- Noor, Ahmed .H. Ismail


The research includes the synthesis and identification of the mixed ligands complexes of M+2 Ions  in general composition  ,[M(Leu)2(SMX)] Where L-leucine(C6H13NO2)symbolized (LeuH) as a primary ligand and Sulfamethoxazole (C10H11N3O3S)symbolized (SMX)) as  a secondary  ligand .

The ligands and the metal chlorides were brought in to reaction at room temperature in(v/v) ethanol /water as solvent containing NaOH. The reaction required the following [(metal: 2(Na+ Leu-): (SMX)] molar ratios with M(II) ions, Were  M(II) = Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II). The UV–Vis and magnetic moment data revealed an octahedral geometry around M(II), The conductivity data show a non-electrolytic nature of the complexes. The antimicrobial activities of ligands and their mixed ligand complexes were screened by disc diffusion method.

Keywords: Sulfamethoxazole(antibiotic), L-leucine, Mixed ligand, Metal complexes, Antimicrobial activity.

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ISSN (Paper)2224-719X ISSN (Online)2225-0638

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