Preparation, Characterization, and Antibacterial Properties of mixed ligand Complexes of L-leucine and Sulfamethoxazole with Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II) ions

Abstract

The research includes the synthesis and identification of the mixed ligands complexes of M⁺² Ions  in general composition  ,[M(Leu)₂(SMX)] Where L-leucine(C₆H₁₃NO₂)symbolized (LeuH) as a primary ligand and Sulfamethoxazole (C₁₀H₁₁N₃O₃S)symbolized (SMX)) as  a secondary  ligand .

The ligands and the metal chlorides were brought in to reaction at room temperature in(v/v) ethanol /water as solvent containing NaOH. The reaction required the following [(metal: 2(Na⁺ Leu^-): (SMX)] molar ratios with M(II) ions, Were  M(II) = Mn(II),Co(II),Ni(II),Cu(II),Zn(II),Cd(II)and Hg(II). The UV–Vis and magnetic moment data revealed an octahedral geometry around M(II), The conductivity data show a non-electrolytic nature of the complexes. The antimicrobial activities of ligands and their mixed ligand complexes were screened by disc diffusion method.

Keywords: Sulfamethoxazole(antibiotic), L-leucine, Mixed ligand, Metal complexes, Antimicrobial activity.