Detection of Acetone Gases Non-Invasive from Diabetic Patient Based on Ages and Gender Factor using Laser Photoacoustics Spectroscopy (LPAS)

Abstract

Has developed a method of laser photoacoustic spectroscopy (LPAS) to measure the concentration of various types of gas tracing to the ppb level. This methods used to detect acetone gas from human breath of diabetic patient based on age and gender. Laser photoacoustic spectrometer operated at maximum laser power of 4,5 W and has a lower limit of detection (BDT) of (2,3 ± 0,2) ppb. The concentration of acetone gas on average for 30 patients with diabetes mellitus are at 624 ppb, whereas the concentration of acetone gas averaged 30 healthy volunteers is as high as 85 ppb. The correlation between the concentration of acetone to gender is not significant. Acetone gas concentration average of 14 male patients amounted to 584 ppb with a correlation of R² = 0,221 and 16 female patients amounted to 660 ppb with a correlation value of R² = 0,016 while the correlation of the concentration of acetone on the patient's age is significant in the amount of R² = 0,7094. For healthy volunteers, almost no correlation between the concentration of acetone gas to the age or gender of healthy volunteers. If age increases, the concentration of acetone in the body will increase.

Keywords: Laser Photoacoustic Spectroscopy (LPAS), acetone gas, diabetes mellitus