Preparation , Characterization and Antimicrobial activities of {Fe(II),Co(II),Ni(II),Cu(II),and Zn(II)}Mixed Ligand Complexes Schiff base derived from Cephalexin drug and 4(dimethylamino)benzaldehyde with Nicotinamide

Abstract

New Schiff base ligand (Z)-7-(2-(4-(dimethylamino)benzylideneamino)-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid = (HL)was prepared via condensation of Cephalexin and 4(dimethylamino)benzaldehyde in methanol . Polydentate  mixed ligand  complexes were obtained from 1:1:2  molar ratio reactions with metal ions and HL, 2NA  on reaction with MCl₂ .nH₂O salt yields complexes corresponding to the formulas [M(L)(NA)₂Cl] ,where M = Fe(II),Co(II),Ni(II),Cu(II),and Zn(II) and   NA=nicotinamide .

The 1H-NMR, FT-IR, UV-Vis and elemental analysis were   used for the characterization of the ligand. The complexes were structurally studied through AAS, FT-IR, UV-Vis, chloride contents, conductance, and magnetic susceptibility measurements. All complexes are non-electrolytes in DMSO solution. Octahedral geometries have been suggested for each of the complexes.

the Schiff base ligands function as tridentates and the deprotonated enolic form is

preferred for coordination. In order to evaluate the effect ofthe bactericidal activity, these synthesized complexes, in comparison to the uncomplexed Schiff base has been screened against bacterial species., Staphylococcus aureus,Escherichia coil and the results are reported.

Key words:(Cephalexin drug, Nicotinamide ,mixed ligand) Complexes, Antibacterial activities, and spectral studies