Artificial Neural Network based Cancer Cell Classification

Abstract

This paper addresses the system which achieves auto-segmentation and cell characterization for prediction of percentage of carcinoma (cancerous) cells in the given image with high accuracy. The system has been designed and developed for analysis of medical pathological images based on hybridization of syntactic and statistical approaches, using Artificial Neural Network as a classifier tool (ANN) [2]. This system performs segmentation and classification as is done in human vision system [1] [9] [10] [12], which recognize objects; perceives depth; identifies different textures, curved surfaces, or a surface inclination by texture information and brightness.

In this paper, an attempt has been made to present an approach for soft tissue characterization utilizing texture-primitive features and segmentation with Artificial Neural Network (ANN) classifier tool. The present approach directly combines second, third, and fourth steps into one algorithm. This is a semi-supervised approach in which supervision is involved only at the level of defining structure of Artificial Neural Network; afterwards, algorithm itself scans the whole image and performs the segmentation and classification in unsupervised mode. Finally, algorithm was applied to selected pathological images for segmentation and classification. Results were in agreement with those with manual segmentation and were clinically correlated [18] [21].

Keywords: Grey scale images, Histogram equalization, Gausian filtering, Haris corner detector, Threshold, Seed point, Region growing segmentation, Tamura texture feature extraction, Artificial Neural Network(ANN), Artificial Neuron, Synapses, Weights, Activation function, Learning function, Classification matrix.