Cu(II) and Ni(II) Complexes of Sulfamethazine Mixed with Pyrimethamine: Synthesis, Characterization and Antimicrobial Study

Abstract

Two novel mixed ligand metal –drug complexes of sulfamethazine and pyrimethamine were prepared using CuCl₂.2H₂O and NiCl₂.6H₂O.The complexes were characterized by elemental analysis, melting point determination, molar conductivity, FT-IR and Uv-Visible spectroscopy. Based on the analytical and spectra data the complexes were formulated as [M(SUFPRM)Cl₂.XH₂O,(SUFPRM)=Sulfamethazine+Pyrimethamine, M=Cu, Ni. And the complexes formed possessed octahedral geometry. In the complexes, sulfamethazine and pyrimethamine acted as bidentate ligand coordinating through the sulfonamide N-atom and the pyrimidinicN-atom. The complexes have been tested in vitro against a number of pathogenic bacteria[g+][Eschericha coli, Proteus specie, Klebsiella pneumonia, Salmonella typhi and Bacillus]by using paper disc method. Obtained results indicated that the metal complexes exhibited better antimicrobial activities as compared to the ligand.

Keywords: Sulfamethazine, Pyrimethamine, metal-drug complexes, ligands, antimicrobial properties.