Assessment of Some Cardiac Biomarkers in Adult HIV Seropositives in Nnewi, Nigeria.

Abstract

Human Immunodeficiency virus (HIV) infection is associated with increased of developing heart disease. Information on cardiac status in HIV infected in Nigerians is lacking. We assessed the impact of HIV infection on serum Myoglobin, Troponin, total CK, CK-MB, LDH and AST of HIV infected adults presenting at Nnamdi Azikiwe University Teaching Hospital Nnewi, Anambra State.

The aim of this study is to determine some cardiac biomarkers in adult HIV seropositive participants, blood samples collected from the 300 randomly recruited participants were used for HIV screening, CD4⁺ T cell count, serum Myoglobin, Troponin, total CK, CK-MB, LDH and AST. Standard Laboratory methods were used for the analysis. The results showed that the mean serum Myoglobin and Troponin levels were significantly higher in symptomatic HIV participants not on antiretroviral therapy (ART) compared with asymptomatic HIV participants at P< 0.05, in each case. Also, the mean serum Myoglobin and Troponin levels were significantly higher in symptomatic HIV participants not on ART compared with HIV asymptomatic HIV participants at P<0.05 in each case. Again, the mean serum total Creatine kinase, CK-MB, LDH and AST were significantly higher in symptomatic HIV participants not on ART compared with asymptomatic HIV participants at P<0.05 respectively. Similarly, the mean serum total Creatine kinase, CK-MB, LDH and AST were significantly higher in symptomatic HIV participants not on ART compared with HIV seronegative control subjects at P<0.05 in each case. Once again, the mean serum total Creatine kinase, CK-MB and AST were significantly higher in asymptomatic HIV participants compared with HIV seronegative control subjects at P<0.05 respectively. Increased levels of some cardiac markers were seen in HIV infected participants.

Keywords: HIV, cardiac markers, participants.