Synthesis and Antimicrobial Activity of Novel of 2,3-Disubstituted Quinazolin 4(3H)- One Derivatives

Abstract

Aseries of novel derivatives of 2,3-disubstituted quinazolin4(3H)-ones have been synthesized from anthranilic acid and p-methoxybenzoylchloride.The structures of the newly synthesized compounds have been established on the basis of their m.p., TLC, IR,UV,Vis and 1H NMR data.These synthesized  compounds were evaluated for their antimicrobial activity.The results showed that some of these derivatives have good antimicrobal activities when compared with standard antibiotic .

Keywords: Quinazolinone, Antimicrobial activity,Azo compound , Azetidinone