Suzuki-Miyaura Cross-Coupling Reaction Based on Novel Palladium(II) Diphenylphosphine Derivative Catalyst
Abstract
The synthesis and characterization of palladium complexes ((CH3)3SiC6H4PPh2)2PdCl2,4a, and ((CH3)3SiC12H8PPh2)2PdCl2, 4b, containing phosphine (CH3)3SiC6H4PPh2, 3a and (CH3)3SiC12H8PPh2, 3b ligands are reported. The phosphine ligands are prepared conveniently in high yield by treatment of the corresponding 1,4-dibromoarene with one equivalent of butyl lithium, and one equivalent of ClPPh2 at -78 °C under an atmosphere of argon. The palladium complexes are synthesized by the reaction of Pd(cod)Cl2 with two equivalent of the above mentioned phosphine ligands. The new complexes were fully characterized by spectroscopic methods and elemental analysis. Furthermore, the use of the palladium (II) complexes of such system as pre-catalysts for the Suzuki-Miyaura coupling of some arylbromides and arylchloride with substituted phenyl boronic acid has been tested.
Keywords:1,4-dibromoarene, Palladium complex, Suzuki coupling, catalyst.
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ISSN (Paper)2224-3224 ISSN (Online)2225-0956
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