HIV-2 Reverse Transcriptase using Chemical Similarity Process of Reducing Viral Attack and Increasing CD4 Counts in HIV-Infected Patients

Abstract

The aim of this study is to examine the Chemical processes focused to reduce viral attack and increasing CD4 counts, HIV viral load after initiation of combination antiretroviral treatment. However by purchasing and assaying of selected top-scoring compounds from the library active anti-HIV agents are created. Subsequent synthesis and assaying of S10087 analogs proposed by further computational analysis yielded anti- HIV agents. Thus, with the aid of computational tools, it was possible to evolve a false positive into a true active. Antiretroviral treatment–naive, chronically HIV-infected persons (n = 1376 and n = 1605 for each of the 2 cohorts) are untreated. During the observation period (5 months), at least 1 HIV RNA level and 2 CD4 cell counts may be stable. Approximately 35% were nonwhite, and 45% had risk factors. Currently, the data would generally support initiation of HAART in patients with CD4 cell counts more than 350 cells/µl. However, from the strong potential for confounding in observational studies and the lack of adjustment for lead-time bias in many analyses, it is not possible to rule out possible long-term detrimental effects of earlier use of HAART. In chemical process we can use these chemicals and it is possible to reduce the critical bond in HIV virus and increase the amount of CD 4 counts.