Synthesis and Characterization of 2-Ethoxy Isobutryl Acid Hydrazide and 2-Ethoxy Isobutryl Aceto Hydrazone and Its Metal Complexes with Co(II), Ni(II) and Cu(II)

Abstract

Complexes of Co(II), Ni(II) and Cu(II) derived from 2-ethoxy isobutryl acid hydrazide (EIAH¹) and 2-ethoxy isobutryl aceto hydrazone (EIAH²) have been synthesized and characterized by elemental analysis, FT-IR, molar conductance, UV – visible spectra, ESR, thermal analysis and magnetic susceptibility. The complexes are coloured, stable in air and exhibit coordination number of 4 or 6. Analytical data showed that all the complexes exhibited 1:2 (metal:ligand) ratio. The changes observed between the FT-IR and UV – visible spectra of the ligands and of the complexes allowed us to establish the coordination mode of the metal in complexes. Presence of coordinated water molecules in Co (II) and Ni (II) complexes is confirmed by TGA studies. The conductivity data show that all these complexes are non electrolytes. The solubility test on the ligands and its metal(II) complexes revealed their solubility in dimethylsulphoxide (DMSO). The ligands and metal complexes show a good activity against the bacteria; B. Subtilis, E.coli and S.aureus and fungi A.niger, A.flavus and C.albicans. The antimicrobial results also indicate that the metal complexes are better antimicrobial agents as compared to the ligands.

Keywords: Synthesis, hydrazine, hydrazone, metal complexes, characterization