Spectrophotometric Method for the Estimation of Meropenem in Pure and in Market Formulation Meronem

Abstract

Cost effective, sensitive, rapid and simple spectrophotometric method was described for the determination of Meropenem in pure form and in pharmaceutical formulations. The proposed methods were based on the formation of chelating complex between meropenem and gold ion (III). This method was applied for the determination of drug meropenem in pharmaceutical formulation meronem and enabled the determination of the selected drug in microgram quantities The colored species has an absorption maximum at 477 nm for MRP-Au(III) complex and obeys beer’s law in the concentration range 15-70 µg/mL of Meropenem. The molar absorptivity was 0.818 x10^-3 and sandell’s sensitivity was 4.6883x10^-7. The slope is 0.0022. The intercept of the equation of the regression line is -0.0009. The optimum experimental parameters for the reaction have been studied and the validity of the described procedure was assessed. Statistical analysis of the results has been carried out revealing high accuracy and good precision. The proposed method was successfully applied for the determination of Meropenem in pharmaceutical formulation.

Keywords: Meropenem, chelating complex, Spectrophotometry.