Synthesis, Characterization and Antimicrobial Study Of Mixed Isoniazid-Trimethoprim Metal Drug Complexes

Abstract

The Mn²⁺, Fe²⁺, Cu²⁺, Co²⁺, Zn²⁺, Cd²⁺ complexes of mixed  of Trimethoprim- Isoniazid were synthesized. The complexes were characterized using solubility, melting point, conductivity measurement and infrared spectroscopy.Trimethoprim complexes of coordination of the metal to the ligands is through the nitrogen of the pyrimidine group and coordination through the nitrogen of the amine group. The antimicrobial activity of the complexes were carried out against Staphylococcus aureus, Pseudomonas aureginosa, Klebsiella pneumonia, Escherichia coli. The results show that the complexes were more active  than their ligands.

Keywords: Trimethoprim, Isoniazid, synthesis, complexes, characterized, antimicrobial ligands metal.