Microwave Assisted Synthesis, Characterization and Antibacterial Study of Some Novel Schiff's Bases, Thaizolidinone and Chalcone Compounds Derived from Mefenamic Acid

Abstract

This work involves synthesis of some new heterocyclic compounds including thaizolidinone compounds. The new Schiff bases derived from mefenamic acid, which was synthesized by microwave irradiation of mefenamic acid with hydrazine hydrate in absolute ethanol and this amino compound condensation with different aromatic aldehydes in absolute ethanol. Thaizolidinone compounds were synthesized by cycloaddition reaction of mercapto acetic acid to imine group of Schiff bases in dry benzene. The new chalcone derivatives synthesized by the reaction aldehyde with their compounds.  M.P., TLC, CHN, UV, FTIR and NMR spectroscopy has characterized all the synthesized compounds. The biological screening data of the synthesized compounds were also studied.

Keywords: Schiff bases, thaizolidinone, chalcone, antibacterial.