Determination of Fluvastatin Sodium In Pharmaceutical Preparations Utilizing A Modified Carbon Paste Electrode

Abstract

A simple, rapid and sensitive method for the determination of fluvastatin sodium (FLS) in pharmaceutical preparations using two modified carbon paste electrodes were developed. One electrode (sensor A) is based on ion-associations of fluvastatin sodium (FLS) with 5,6 diamino-2-thiouracil hydrochloride (DTUH) and the other (sensor B) with a mixture of FLS -with sodium cobaltinitrite (FLS-CoN) and (FLS-DTUH). Among three different solvent mediators tested, dioctylphthalate (DOPH), exhibited a proper behavior including Nernstian slopes of the calibration curve at 57.78±0.4 and 57.18±0.8mV per decade for sensors A and B. The response times were 8 and 5 s; detection limits 4.9×10⁻⁷ and 2.2×10⁻⁷ M; the concentration range 9.0×10^-7- 2.5×10^-1 M and 7.3×10^-7 -2.5×10^-1M respectively. The present electrodes show good discrimination of fluvastatin sodium (FLS) from several inorganic, organic ions, sugars and some common drug excipients. The sensors were applied for the determination of fluvastatin sodium in pharmaceutical preparations using potentiometric determination, standard addition and the calibration curve methods. The results obtained were satisfactory with excellent percentage recovery comparable and sometimes better than those obtained by other routine methods for the assay

Keywords: key words, Potentiometric, modified carbon paste electrodes, fluvastatin sodium