EPHROPROTECTIVE EFFECTS OF ETHANOLIC EXTRACT OF Solanum Melongena AGAINST CARBONTETRACHLORIDE (CCL4) INDUCED TOXICITY IN RATS

Abstract

Nephroprotective effects of ethanolic extract of solanum melongena against carbontetrachloride (ccl₄) induced toxicity in rats was studied. Serum urea, Na⁺K, chloride, Bicarbonaate were determined using Diacetyl monoxime method, Flame photometery method, Shales and Scale method and Trimetric method. The result for changes in body weight following oral administration of the extract (Solanum melongena) for induced toxicity on rats ranged; 157-127mg, 0.39 – 10.28mg, 5.59-5.08mg, 3.44-13.64mg, 0.85-3.90mg and 6.40-1.65mg for the initial, 3days, 6days, 9days, 12days and 15 days respectively. Effects of oral administration of Solanum melongena on Indices of renal function and relative organ weight in CCl₄ induced toxicity in rats indicates that creatinine(µmol/l) has the highest value of 143.50±13.86 in group5 and the lowest value of 36.80±4.59 in group1. Urea (mmol/l) has the highest value of 8.34±0.86 and the lowest value of 6.38±0.68. Sodium (mmol/l), Potassium (mmol/l), chloride (mmol/l), Bicarbonate (mmol/l) and Relative kidney have the highest values of 125.50±0.77, 5.46±71.00, 102.20±3.74, 21.00±0.44 and 0.91±0.07 respectively.  Administration of carbon tetrachloride has lead to a slight but insignificant increase in the serum level of creatinine, sodium, potassium, chloride and bicarbonate. This indicates that the carbon tetrachloride might not have caused significant damage to the kidneys. Oral administration of ethanolic extract of Solanum melongena for fourteen days increased significantly the serum creatinine levels. Oral administration of the extract alone also led to similar increase in the creatinine level suggesting possible nephrotoxicity of the extract.

Keywords: key words, nephrotoxicity, ethanolic, toxicity, carbontetrachloride