Effect of Graft Ratio PVA-Urea and Different Concentration Blend Polymers on Swelling Ratio

Abstract

The polymeric materials still important parameters for drug delivery research.In the present work two graft polymers PVA-U were prepared from reaction  polyvinyl alcohol PVA  and urea by using two ratio concentration from urea. Were blending 8% PVA-U and 5% Hydroxypropyl methylcellulose HPMC  in different ratio 100:0, 75:25 and 50:50  with using glutaraldehyde as crosslinked agent 0.75 ml/dl. The structure of PVA-U and blend PVA-U/HPMC hydrogel was characterized by Fourier transform infrared spectroscopy FTIR, differential scanning colorimeter DSC and scanning electron microscopy SEM. Studies are made on swelling behavior for all prepared samples in different media of PH (neutral, acidic and alkaline) and deionised water.. It is found that swelling ratio depends on media and proportion of substitutes in graft polymers, in high graft polyvinyl alcohol the swelling ratio increased with pH increased from pH2 < dionized water ≤ PH7 < PH10, But in low graft polyvinyl alcohol the swelling ratio increased with pH increased from pH2 < PH10 < dionized water ≤ PH7. Swelling ratio of polymeric hydrogels was affected by composition blend polymers and it was increased by increasing the concentration of HPMC and decrease time for complete swelling.

Keywords: Blend polymers, Hydrogel polymers, PVA, HPMC, Glutaraldehyde