Synthesis of Some Amidoalkyl naphthol and Benzoxanthene Derivatives by Zinc Oxide Nanoparticles Catalyst Under Solvent Free Condition and Evaluation of Their Antimicrobial and Antioxidant Activities

Abstract

Eco-friendly synthesis method was used to synthesize some amidoalkyl naphthol and benzoxanthene derivatives using zinc oxide nanoparticles under solvent free condition. The corresponding synthesized amidoalkyl naphthols A, B (89.8-90.4%) and benzoxanthenes C, D and E (89.4-93.5%) were found higher yield than other reported methods. Antibacterial activity results of synthesized benzoxanthenes D and E showed activities with zone of inhibition (mm) against all gram negative strains (9-15mm) and gram positive bacterial strains (9-13mm) tested where as benzoxanthene C was active against B. subtilis (8,9,10mm), (10,11,12mm) for both B. subtilis and E.coli. Amidoalkyl naphthol A showed activity against B. subtilis (10, 11, 12mm) only and amidoalkyl naphthol B was active against both B. subtilis (9, 10,12mm) and E.coli (10, 11,15mm). Amongst all, the benzoxanthene C has only shown antifungal activity against C. albicuna (12, 14, 16 mm zone of inhibition) even stronger than the standard fluconazole and amidoalkyl naphthol A, B and benzoxanthenes D, E were inactive against C. albicuna. Except benzoxanthene E, All the remaining synthesized compounds have shown promising antioxidant activities with IC₅₀ values of 24.45, 17.65, 22.6 and 47.56 μg/ml for amidoalkyl naphthol A, B, benzoxanthene C and D as compared to standard ascorbic acid (9.28µg/ml) respectively.

Keywords: Antibacterial, Antifungal, Antioxidant, Amidoalkyl naphthols, Benzoxanthenes

DOI: 10.7176/CMR/11-7-03

Publication date:September 30^th 2019