Synthesis of Complex from Nickel(II) salt and 2-imino-3-(2-hydroxy phenyl)-1-thiazolidin-4-one and Study of its Structure and Antimicrobial activity

Abstract

The ligand 2-imino-3-(2-hydroxy phenyl)-1-thiazolidin-4-one was synthesized by condensation of 2-hydroxy-N-chloroacetylaniline with potassium thiocyanate. The nickel(II) metal complex of the ligand was prepared by refluxing the ligand with hydrated nickel(II)chloride (NiCl₂6H₂O) salt under ethanol. Complex of Ni(II) with heterocyclic ligand has been characterized with the help of elemental analysis, magnetic, ¹H-NMR, ¹³C-NMR, IR and electronic spectral data. IR spectra exhibit the coordination of the ligands to the metal ion through deprotonated phenolic oxygen and heterocyclic nitrogen. All these studies reveal square planar geometry of Ni(II)complex. Synthesized ligand and its complex have also been screened against two bacterial strains, Escherichia coli and Salmonella-typhi and two fungal strains, Aspergillus niger and Penicillum chrysogenum by ‘paper disc’ technique. It has been observed that the antimicrobial activity of metal complex was higher than that of the free ligands.

Keywords: Hetrocyclic ligand, thiazolidinone, (Nickel II) complexes, anti-microbial studies,   electronic spectra

DOI: 10.7176/CMR/14-1-01

Publication date: January 31^st 2022