The Effect of Dielectric Constant On The Kinetics of Reaction Between Plasma Albumin And Formaldehyde In Ethanol- Water Mixtures.
Abstract
This study determined the effect of increased concentration of ethanol solution on the rate of the reaction between plasma albumin and formaldehyde. It was design to investigate the kinetics of reaction between plasma albumin and low concentrations of formaldehyde under pseudo-first order conditions of formaldehyde. The reaction was studied at constant conditions at various dielectric constants and temperatures of 1%, 5%, 15%,20% and 200C 250C, 300C and 370C respectively. The rate constant as a function of different permittivity in ethanol-water mixtures was determined at constant conditions. The dielectric constant of the reaction medium was altered by the addition of the varying amounts of ethanol – water mixtures (1- 25% v/v) in a cuvette and the absorption of 0.51 x10-4 mol dm-3 plasma albumin and 0.27 x10-1 formaldehyde- plasma mixtures at 235 nm were measured. The values of dielectric constants for different aqueous ethanol- mixtures were taken from literature. The values of rate constants of the reaction of between plasma albumin and formaldehyde were found to decreased with the increase in the concentration of ethanol and the reaction was a second order or bimolecular . The Activation energy and the thermodynamic parameters (Gibbs free energy, enthalpy and entropy changes of the reaction) decreased with decrease in dielectric constant of the medium, that is with increase in the proportion of the ethanol component in the solvent mixtures. The dependence of lnk2 vs. reciprocal dielectric constant (1/D ) of this reaction was found be linear with three linear portions indicating three zones, that is three mechanistic changes. Also the correlations between lnk2 and the mole fractions of water and ethanol ( ?H2O and ?EtOH) have shown that there was an increase in rate of the studied reaction in water but a decrease in rate in ethanol mole fraction. This leads us to suggest that the reaction rates were slowed by progressive addition of ethanol . A steady decrease in rate constant with decrease in dielectric constant values was observed with a statistically significant p-value = 0.0013 on a two tailed correlation analysis at 95% confidence assurance.
Key Words; dielectric constant, kinetics , plasma albumin, formaldehyde , ethanol- water mixtures.
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ISSN (Paper)2224-3224 ISSN (Online)2225-0956
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