Electrochemical Stripping Studies of Amlodipine Using Mwcnt Modified Glassy Carbon Electrode

Abstract

The voltammetric behaviour of amlodipine was studied on multiwall carbon nanotubes (MWCNT) modified glassy carbon electrode. The oxidation of amlodipine is irreversible and exhibits a diffusion controlled process which is pH dependent. The oxidation mechanism was proposed in this work. The dependence of the current on pH, the concentration and nature of buffer, and scan rate were investigated to optimize the experimental conditions for the determination of amlodipine. Calibration plots were drawn between stripping peak current and concentration. They are linear within the range from 0.01 to 0.3 µg/mL. The lower limit of detection (LOD) was found to be very low (0.001 µg/mL) on MWCNT. The developed MWCNT modified glassy carbon electrode system was applied to successfully determine amlodipine in commercial pharmaceutical products.

Key Words: Voltammetric, Multiwall Carbon Nanotubes, Amlodipine, Stripping.