Synthesis, mass spectroscopic studies, cytotoxicity evaluation and quantitative structure activity relationship of novel isoindolin-1,3-dione derivatives

Abstract

3-Amino-4,6-diphenyl-2H-pyrazolo[3,4-b]pyridine (5) was synthesized as starting material and investigated as cytotoxic and antitumor agent. Compound 5 reacted with different acid anhydrides to afford the corresponding imides and bisimide derivatives 6-12. Imides 6-12 were tested for their in vitro cytotoxicity against four different cancer cell lines and structure activity relationship^’s (SAR’s) was studied.

Keywords: 2-Thiomethyl-4,6-diphenyl-3-carbonitrilpyridine, Acid Anhydrides, Cytotoxicity.