A Convenient Synthesis of Some Diarylurea and Thiourea Derivatives as Antimicrobial Compounds

Abstract

A simple and efficient method has been developed for the synthesis of unsymmetrical 1,3-diarylurea and thiourea derivatives (3 and 4)  from phenylisocyanate or phenylisothiocyanate with  various aromatic amines. Unsymmetrical bis-diarylthiourea derivative (8b) reacted with diethyl malonate, ethyl chloroacetate and phenyl hydrazine, while (12) reacted with hydrazine hydrate, hydroxylamine hydrochloride, ethyl cyanoacetate and malononitrile. All compounds are characterized by I.R, ¹H-NMR, ¹³C-NMR and MS spectral data. A comparison of synthesis of the products by conventional method and by microwave has also been undertaken. The screened antibacterial activity of the products has been recognized.

Keywords: Phenylurea, Phenylthiourea, Thiazolidine, Microwave, One pot reaction, Antimicrobial activity