Physico- chemical and Pharmacological Characteristics of mixed ligand complex of Cu (II) with Famotidine and Methionine

Abstract

Mixed ligand complex of Cu (II) with Famotidine as one ligand and Methionine as second ligand was prepared. The complex was characterized on the basis of elemental analysis, electronic and I.R. Spectral and particle size measurements. Pharmacological effects of the complex on gastric secretion in pylorous ligated rats and gastric emptying rate in albino rates were also studies. It was found that the complex in dose range 200-500 mg/kg produced significant reduction in total and free acid and it had no effect on gastric emptying rate.