Determination of Cefadroxil Antibiotic by an Analytical Method

Abstract

This paper includes the most relevant analytical methodology used for the determination of Cefadroxil antibiotic. Cefadroxil is an orally active semi-synthetic ?-lactam antibiotic from the cephalosporin group, characterized by its prolonged action. This compound is effective against susceptible bacteria causing infections of the urinary tract, skin and soft tissue as well as pharyngitis and laryngitis. A  variety of analytical methods have been proposed for the determination of cefadroxil in biological fluids and pharmaceutical samples. The spectrophotometric method using oxidative coupling reaction has been performed in which chloranillic acid & MBTH has been used as reagent at 535 nm & 420 nm absorbance with linear range of 15-415 ?g/ml & 1-12?g/ml. Speed of analysis has become of paramount importance in many application areas, such as in pharmaceutical and clinical analysis, in order to increase throughput and reduce costs. In this way, the recently invented methods offer new practical possibilities for increasing their efficiencies.

Keywords: Cefadroxil(CFL); Antibiotics; Biological and pharmaceutical samples;