Verification of [4(1,2-Di Hydro -4,6-Dihydroxy Pyrimidine -2- Yh Thio)-3-Hydroxy-5-(2,2-Dimethyl-1,3-Dioxolan-4-Yl) Furan-2(5H)One] Properties as Antioxidants in Experimental Animals Induced with Diabetes.

Abstract

Diabetes mellitus (DM) associated with Oxidative stress which indicates the imbalance between reactive oxygen species (ROS) and defensive antioxidants system. In this work it has been proved that compound [4(1,2-di hydro -4,6-dihydroxy pyrimidine -2- yH thio)-3-hydroxy-5-(2,2-dimethyl-1,3-dioxolan-4-yl) furan-2(5H)one](3A) works as antioxidant compared with other used in this study. Rabbits used  were divided into the induced diabetic rabbits (n=5) , rabbits control (n=5), treatment groups  with following antioxidants  aspirin (n=5) ,GSH(n=5) ,Vitamin C (n=5) and with preparation compound  (3A) (n=5)  which  believed to be as antioxidants, The results show that levels of serum glucose and MDA in diabetic rabbits  were  significantly increased (p<0.000) for both as compared with control group and significantly decreased in treatment groups with aspirin, GSH, Vit C, and   (3 A) while the level of membrane protein has been significantly decreased (p<0.000) as compared with control group and significantly decreased in treatment groups with aspirin, GSH, Vit C, and  (3 A), these results verified that compound ( 3A) considered  as antioxidant, but another study needs to detect the ability to used as drug.

Keyword: Diabetes Mellitus, Malondialdehyde(MDA), Aspirin, Reduced glutathione ( GSH), 3A.