Comparison of Immunoreactivity Serum Neuregulin 1 in Bataks Ethnic with Schizophrenia Paranoid and Bataks Ethnic Healthy Control

Abstract

Protein measurements in blood are often used to investigate the pathological contribution of individual molecules. Neuregulin1 (NRG1) proteins influences the development of white matter connectivity and is implicated in genetic susceptibility in schizophrenia (NRG1  proteins in rat, Frenzel, NRG1 1 genetic variation Fei Wang). Neuregulin 1 affects the regulation of central nervous system myelination by inducing the migration and differentiation of oligodendrocytes in the CNS. The objective of the present study is to make comparison of immunoreactivity serum Neuregulin 1 in Bataks ethnic with schizophrenia and Bataks ethnic healthy control. Serum samples were collected from 42 Bataks ethnic with schizophrenia (21 men, 21 women) and 30 control subjects (15 men, 15 women). Neuregulin 1 was measured by ELISA using antibody against NRG 1 beta 1. The differences between Bataks ethnic with schizophrenia and healthy control were assessed using Mann Whitney test (significant value p < 0,05). Mean immunoreactivity of serum Neuregulin 1 in schizophrenic patients 14,51 pg/ml (SD ± 6,81) and mean immunoreactivity of serum neuregulin 1 in control subjects 13,12 pg/ml (SD ± 2,49). Immunoreactivity of serum neuregulin 1 in Batak ethnics with schizophrenia was significantly higher than in Bataks ethnic healthy control (p=0,036).

Keywords: serum neuregulin- schizophrenia- Bataks ethnic