Evaluation of High Density Lipoproteins Characteristics in Type 2 Diabetics

Abstract

To investigate the characteristic features of high density lipoproteins in type 2 diabetes mellitus patients, we examined the lipid parameters, quantitated glucose and insulin levels along with the apolipoprotein ratios. Using radial immunodiffusion, colorimetric, flourimetric and ultracentrifugation methods the values of the parameters were obtained. We observed a moderate elevation of the Hdl/Ldl cholesterol and apolipoprotein A-1/A-11 ratio which are exponents risk factors in the exacerbation of atherosclerosis. Both males and females show higher level of these parameters when compared with controls and were markedly higher (p>0.05). We also noticed a marked elevated correlation (r=0.891, p<0.01) between the high density lipoprotein and the apoprotein A-1/A-11 ratio. Understanding that Hdl of diabetic patients are enriched with triglyceride and cholesterol depleted we reason that changes that may occur as a result of poor management of diabetes has the ability to decrease the antiatherogenic effect of high density lipoprotein. We could advance evidence that an elevated apolipoprotein A-1/A-11 ratio in type 2 diabetic patients has the capacity to inhibit the development of atherosclerosis.

Keywords: High density lipoprotein, lipids, characteristics, type 2 diabetes