Congenital Malformation Pattern in Duhok City

Abstract

This study was undertaken to estimate the prevalence of neonatal malformations in Duhok province by reviewing a database of all deliveries from January 1^st 2006 to December 30^th 2010 in Azadi hospital, The files of the delivery room and neonatal registry records were studied for all obvious congenital anomalies.During the five years study period a total of 79227 babies were born  at Azadi University hospital of which 1760  were stillbirth and 369 were surviving babies who had one or more congenital anomaly giving an incidence of 4.65/1000 live birth. The most involved system was the Central Nervous System forming nearly half of the entire defects (44.98%) with an incidence of 2.09/1000 birth, Hydrocephalus, Myelomeningocele and microcephaly together were the most prevalent CNS anomalies among all reported congenital malformations, followed by congenital heart diseases (0.65 /1000) with ventricular septal defect (VSD) being the most common lesion. The proportion of live born infants with chromosomal anomalies was 32 cases, contributing 8.67% of all malformations. Down syndrome was the leading defect followed by Turner syndrome , while musculoskeletal ,genitourinary and unclassified multiple system anomalies scored the incidence of  (0.26/1000), (0.25/1000) and (0.35/1000) respectively. The less common defects were sensory (0.21/1000), gastrointestinal (0.17/1000), teratoma(0.15/1000) and respiratory (0.08/10000).

Keywords: Genetic disorders ,Birth defects prevalence, Genetic counseling .