Effect of Zinc Supplementation on Glycemic Control, Lipid Profile, and Renal Functions in Patients with Type II Diabetes: A Single Blinded, Randomized, Placebo-Controlled, Trial

Abstract

This study was conducted to evaluate the effect of zinc supplementation on glycemic control, lipid profile, and kidney functions in patients with type 2 diabetes mellitus attending the diabetic centre of Alnoor, Specialized Hospital, in Makkah, Saudi Arabia .A single blinded, randomized, placebo-controlled, trial was conducted. Patients (n=60) were randomly allocated into two groups: zinc group, and placebo group, treatment was given for 8 weeks. Fasting blood glucose (FBG), glycated hemoglobin (HbA1c%), kidney functions and lipid profile were assessed at baseline and after 8 weeks. Results showed that FBG, HbA1c%, lipid profile, and kidney functions were significantly reduced in zinc group after 8 weeks compared to their levels before supplementation. Moreover, FBG, cholesterol, LDL, and LDL/ HDL ratio were significantly decreased, while HDL was significantly increased in zinc group compared to those in placebo group. Zinc may have supplementary benefits in the routine management of adult DM.

Keywords: type 2 diabetes, zinc, placebo, HbA1c%, lipids, kidney functions