Efficacy of Plant Extracts Against Multi-Drug Resistant Escherichia Coli from Urinary Tract Infection

Abstract

Introduction: Urinary tract infections (UTI) are among the most commonly prevalent infections in clinical practice. E. coli is the causative agent in about 85% of community acquired urinary tract infections, followed by Klebsiella that accounts for 6 to 17% of such infections. Objectives: Present study was conducted to evaluate the antibacterial potential of five plants used against E.coli causing UTI Methods: A total of 40 pregnant women were screened for significant a symptomatic bacteriuria. All the subjects were clinically identified to have no signs and symptoms of UTI. Clean catch midstream urine samples were collected for both groups. Urine samples were examined microscopically and cultured and incubated at 24 hrs at 37°C. Isolated organisms were identified and characterized on the basic of morphological, cultural and biochemical characteristics. Results:  A total of 40 urine sample were analyzed for isolation of multidrug resistance E. coli. Out of which 20 samples showed significant bacteriuria. The bacteria identified using biochemical characteristic as E. coli. In general, over all 100% of isolates were resistant to Rifampicin, 90% of isolates to Ampicillin, 85% of isolates to Nalidixic acid, 75% to Gentamycin, and 65% to OflaxacinConclusions: The use of plants extracts with known antimicrobial properties can be of great significance for therapeutic treatments. Results of antimicrobial susceptibility test showed marked differences among bacterial isolates in their susceptibility and resistance patterns to a particular antibioticbasis.

Keywords: Urinary tract infections, Escherichia coli, multidrug resistant, plant extracts