Effectiveness of Monoclonal Stool Antigen Immunoassay for Detection of Helicobacter pylori in Iraqi Patients

Abstract

There are currently several methods to test for H. pylori infection, endoscopy tests (Invasive) and non-endoscopic tests (Noninvasive). The aim of current study was to validate stool antigen tests (SAT) and rapid urease test (RUT) findings, used histopathological examination as the gold standard for diagnosis of H.pylori and comparison diagnostic specificity and sensitivity between non-invasive test findings. Gastric antral biopsy specimens and stool sample were taken from each patient to confirm infection of H.pylori by (histology, SATand RUT). While comparing the results of the tests was, sensitivity and specificity of RUT were 92.7% and 90%, and 96.2% and 81.8% for the SAT. Positive predictive value and negative predictive values for RUT were 96.2% and 90% and 92.7%and 81.8% for SAT. Round off that the rapid stool antigen test can be served as an alternate to RUT for H. pylori infection diagnosis in Iraqi patients.

Keywords:H.pylori, non-invasive tests, H. pylori diagnosis, rapid Stool antigen test.