Immune Response to Hepatitis B Virus Vaccine

Abstract

Hepatitis B virus (HBV) infection is a major public health problem and its outcome depends on the kinetics of the virus host interaction and in particular on the strength of the immune response.this study was done to illustrate some immunological in vaccinees and effectiveness of HBV vaccine in vaccinees groups . This study was conducted from September , 2011 to October, 2012 .   ELISA  assay was used for detection  of  hepatitis B virus surface antigen  as well as  IgM- anti hepatitis  B-core antigen  . This study was also include measurement of anti- HBsAg level  to detect the immune response in vaccinees  . It was found that significant differences in the antibodies levels  according to post vaccination periods  and the highest antibodies level in male and female was reached after 90 days post 3^rd dose of vaccination , it was  124.85 mIU/ml and 155.94 mIU/ml in male and female respectively.  There was also significant differences in (IL-2 it was found that the highest level of IL-2 was reached  27.21 pg/ml and 33.94 pg/ml  90 days post 3^rd dose  of vaccination in male and female respectively.

Keyword: Hepatitis B vaccinees, anti-HBsAg, HBsAg, anti-HBcAg, IL-2