Comparative Study of Serum Albumin, γGT and LDH levels in HIV Coinfection with Hepatitis B Virus in Relationship with CD4 Count

Abstract

This study was designed to determine the serum albumin, GGT and LDH level in relationship with the CD4 count and hepatitis B and C coinfection in HIV patient. Sixty HIV patients aged 16 to 75 years classified according to the CD4 cell count value and with reference to HBV/HCV co-infection status were studied. Viral Immunochemical status of the patients was determined by ELIZA and Immunoblotting. CD4 cell count was estimated by flow cytometry while the plasma LDH, GGT and Albumin was estimated biochemically by spectrophotometry. The results showed a significantly higher  mean value in the plasma level of  albumin in HIV-monoinfected  patients with CD4 count of between 251-399cells/µl and  those with values of  ≥400 cells /µl than those with CD4count between 0-250 cells/µl. with p<0.05.  The results showed a significantly higher  mean value in the plasma level of  albumin in HIV-HBV patients with CD4 count of between 251-399cells/µl and  those with values of  ≥400 cells /µl than those with CD4count between 0-250 cells/µl. with p<0.05.  In conclusion there was a biochemical alteration in the plasma level of Albumin in the HIV monoinfected and HIV-HBV patients and this significant alteration  was also found to be directly proportional to CD4 cell count hence the need for the estimation of these parameters in the management of HIV infection. None of the patients was coinfected with HCV.

Keywords: : Serum Albumin, γGT, LDH HIV Coinfection, Hepatitis B Virus, CD4