The Immune Concerns for Chronicity of Sars-cov-2 Infection in Man

Abstract

The objective of the p3resent opinion was disclose some immune features of chronic sars-cov-2 human infection. The extension of sars-cov-2 infection manifestation up to 12 months or more beyond the onset of the clinical infection is considered to be chronic. The problem of chronicity gain its importance impart by the residence of infecting sars-cov-2 virus in a reserve organ and frequently releasing it to the blood circulation reaching other body parts causing continual stimulation of hosting immune system with an outcomes of an immune over-reactions, immune weakening and immune mediated diseases. The immune features of the chronicity in covid-19 infections appeared to be different in different patients, though the presence of in-common ones . There was an array of the immune system behavior noted in such chronicity as; Prolonged adaptive immune activation and cellular exhaustion, weakening, over-reaction as well as inflammatory and immune tissue injuries. Gullain Barre autoimmune disease was currently documented to be induced by chronic sars-cov-2 virus infection.

Keywords: Chronicity, covid-19, disease ,immune, inflammation ,Sars.

DOI: 10.7176/JHMN/86-04

Publication date: February 28^th 2021