Efficacy of Misoprostol In Inducing Abortion in 2nd Trimester With Previous One Cesarean Section

Abstract

Objective: To determine the efficacy of misoprostol for inducing the abortion in 2nd trimester with previous one cesarean section. Study Design: Descriptive case series. Setting: Department of Obstetrics & Gynaecology, Nishtar Medical College and Hospital Multan. Material and Methods: The sample included 139 patients having pervious one cesarean section with gestational age 14-20 wks assessed on ultrasound and having an indication for termination of pregnancy like IUD, fetal anomalies (neural anomaly, cardiac anomaly), medical disorder hypertension, diabetes mellitus. General physical examination was done by the researcher. Investigations including complete blood count, complete urine examination, random blood sugar, liver and kidney function tests, coagulation profile were carried out. The researcher placed misoprostol 200µg per vaginally every 4 hourly with overnight rest maximum for 72 hours. Efficacy of misoprostol was judged in terms of success rate in achieving termination. Termination of pregnancy was considered successfully if cervical os progressively dilated and both fetus and placenta expelled within 72 hours after insertion of 1st dose of misoprostol without surgical intervention. Results. A total of 139 cases fulfilling the inclusion criteria were enrolled to determine the efficacy of misoprostol for inducing abortion in 2nd trimester with previous one cesarean section. Among these patients 84.89% (n=118) were treated effectively, 15.11% (n=21) were not effectively treated. Conclusion; Misoprostol for inducing the abortion in 2^nd trimester with previous one cesarean section is effective for expulsion of the fetus and placenta.

Keywords; Abortion, Misoprostol, second trimester.