Raised CA-125 Levels in Patients with Suspected Cases of Ovarian Malignancy

Abstract

Objective:- To determine frequency of raised CA-125 levels in patients with suspected cases of ovarian malignancy. Material and methods:- This Descriptive cross sectional study was conducted in the Department of Obstetrics and Gynecology, Nishtar hospital Multan from February 2016 to  April 2017. One hundred and eleven cases of adnexal mass were admitted in Wards of Department of Obstetrics & Gynecology, Nishtar Hospital Multan with suspicion of ovarian malignancy. Results:- Mean age of the patients was 47.84±10.7 years. 70(63.1%) women were para 1–4 and 16(14.4%) para 5 or above.  Family history of ovarian cancer was present in 60 patients (54.1%). In our study, frequency of raised CA-125 levels was 82.0%; (91/111) among patients with adnexal mass. Mean CA-125 levels were 938.66±697.7 µ/ml. Raised levels of CA-125 were associated with advance age, low parity and family history of ovarian cancer. Conclusion:- In our study, frequency of raised CA-125 levels was 82.0% among patients with suspicion of ovarian cancer. Raised CA-125 levels were associated with advance age, low parity and family history of ovarian cancer.

Key Words:- Ovarian carcinoma, raised CA-125 levels, adnexal mass