Intra-Articular ozone or Hyaluronic acid Injection in Patients with Knee Osteoarthritis

Abstract

Objective: To compare the effect of ozone and hyaluronic acid for pain relief in patients of knee osteoarthritis.  Study Design: Randomized clinical trial. Place of study: Study was conducted in the Pain Managment department of the Bahawal Victoria Hospital, Bahawalpur over a period of January, 2018 to January, 2019. Duration of study: study was completed in one year from February 2016 to February 2017. Methodology: A total of 200 patients were included in the study through non probability consecutive sampling and divided into two groups (A and B) through lottery method. Collected data was entered and analyzed by using SPSS version 24, mean and standard deviation were calculated for numerical data like age, and Visual Analog Scale (VAS scale) and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC score). Frequency and numbers were calculated for qualitative data like gender. Paired t-test and chi square test were applied to see significance of data, p-value less than or equal to 0.05 was considered as significant. Results: Mean age, BMI, WOMAC and VAS of ozone therapy’s patients was 55.85±4.56 years, 26.01±1.75 kg/m², 42.23±7.30 and 7.35±1.90 respectively. Mean VAS, WOMAC pain, WOMAC stiffness, WOMAC function and WOMAC total of the HA therapy’s (before) patients was 6.62±2.25, 8.62±1.89, 1.91±1.08, 27.59±2.64 and 37.67±4.06 respectively. While, the mean VAS, WOMAC pain, WOMAC stiffness, WOMAC function and WOMAC total of the HA therapy’s (after) patients was 3.08±1.68, 2.97±1.21, 1.0±0.48, 13.36±2.39 and 17.40±3.64 respectively. According to paired sample t test, the difference was statistically significant at (p<0.05).Conclusion: Results of our study concluded that ozone oxygen and hyalorunic acid is equally effective for relieve of pain in knee osteoarthritis. There was no significant difference among groups which shows that no drug have superiority on each other.

Keywords: Osteoarthritis, Intraarticular, Ozone, Hyalorunic acid, Pain.

DOI: 10.7176/JMPB/52-17