Journal of Natural Sciences Research
Synthesis, Characterization and Antimicrobial Investigations of (Ag, Cu, Ni, Co,Mn andHg)Complexes With Schiff Base Derived From PVA andErythro-Ascorbic Acid Derivative
Abstract
The aim of this work is the synthesis of new Schiff base derived from PVA and Erythro-ascorbic acid derivative (pentulosono-?-lactone-2,3-enedianisoate) and its metal complexes of biological significance. All synthesized compounds were characterized by Thin layer chromatography (TLC) and FTIR spectra and aldehyde was also characterized by (U.V-Vis), 1HNMR, 13CNMR and mass spectra.
The synthesized Schiff base & its metal complexes were screened for theirinvitro antimicrobial activity against five pathogenic bacteria (Escherichia coli, Shigella dysentery,Klebsiellapneumonae,Staphylococcusaureus, Staphylococcus Albus) and two fungal (Aspergillus Niger,Yeast).The biological activity ofall complexes is higher than free Schiff base ligand andfollows the order: polymer < pol-Mn< pol-Ni< pol- Co ? pol-Cu ? pol-Ag ? pol-Hg.This means that metal chelation significantly affects the antimicrobial behavior of the organic ligand.
Keywords: Schiff base, polymer metal complexes, antibacterial, antifungal, activity.
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ISSN (Paper)2224-3186 ISSN (Online)2225-0921
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