Synthesis, Characterization and Antimicrobial Investigations of (Ag, Cu, Ni, Co,Mn andHg)Complexes With Schiff Base Derived From PVA andErythro-Ascorbic Acid Derivative

Rasmia M. Rumez, Maha A. Younus, Taha M. Salih, Bassam I. Khalil

Abstract


The aim of this work is the synthesis of new Schiff base derived from PVA and Erythro-ascorbic acid derivative (pentulosono-?-lactone-2,3-enedianisoate) and its metal complexes of biological significance. All synthesized compounds were characterized by Thin layer chromatography (TLC) and FTIR spectra and aldehyde was also characterized by (U.V-Vis), 1HNMR, 13CNMR and mass spectra.

The synthesized Schiff base & its metal complexes were screened for theirinvitro antimicrobial activity against five pathogenic bacteria (Escherichia coli, Shigella dysentery,Klebsiellapneumonae,Staphylococcusaureus, Staphylococcus Albus) and two fungal (Aspergillus Niger,Yeast).The biological activity ofall complexes is higher than free Schiff base ligand andfollows the order: polymer < pol-Mn< pol-Ni< pol- Co ? pol-Cu ? pol-Ag ? pol-Hg.This means that metal chelation significantly affects the antimicrobial behavior of the organic ligand.

Keywords: Schiff base, polymer metal complexes, antibacterial, antifungal, activity.


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ISSN (Paper)2224-3186 ISSN (Online)2225-0921

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