Isolation of Antibacterial Compounds from Garcinia Cf Cymosa

Abstract

Garcinia cf cymosa as part the family of Guttiferae was found out containing some active components of antibacterial i.e. xantone, flavonoid, terpenoid and phenolic derivatives. This study was intended to investigate the principal components as antibacterial through bioassay guided isolation using n-hexane, dichloromethane, and ethyl acetate as solvent. Based on this study have been isolated three xanthone derivatives i.e. ?-mangostin(1), ?-mangostin(2) and (-)- epicatechin(3). Compound 1 showed strong activity at concentrations of 100 ppm against Shigella dysentriae where comp.3 demonstrated significant antibacterial activities against Shigella dysentriae and Pseudomonas auregynosa at the same dose.

Keywords: Garcinia cf cymosa,(-)-epicatechin,Shigelladysentriae, Pseudomonas auregynosa