Isolation of Phospholipase A2 Inhibitor from Cryptolepis oblongifolia (Meins) Schltr

Saifullahi Umar, Ahmed Abubakar, Hajara Ibrahim, Balarabe Abdullahi Sallau, October Natasha

Abstract


Chromatographic studies of Cryptolepis oblongifolia yielded a triterpene fatty acid (Oleanyl Erucoate) which was identified through spectroscopic means. The inhibitory effect of the isolated compound on PLA2 of Naja nigricollis venom was investigated. The 13CNMR of  the isolated compound showed carbonyl functional group and oleanane type of structure while EIMS analysis revealed that, the compound was Oleanyl Erucoate with molecular weight of [M+1] 735. The triterpene fatty acid inhibited the PLA2 in a dose dependent fashion with an inhibition binding constant (ki) of 1.74 mg/mL. The activity of this compound might provide a scientific basis for the local use of Cryptolepis oblongifolia in traditional medicine for the treatment of inflammation or contribute in the development of  novel drugs that could serve as potential antivenin.

Keywords: Naja nigricollis venom, Oleanyl erucoate, Inhibition


Full Text: PDF
Download the IISTE publication guideline!

To list your conference here. Please contact the administrator of this platform.

Paper submission email: JNSR@iiste.org

ISSN (Paper)2224-3186 ISSN (Online)2225-0921

Please add our address "contact@iiste.org" into your email contact list.

This journal follows ISO 9001 management standard and licensed under a Creative Commons Attribution 3.0 License.

Copyright © www.iiste.org