A Comparative Study for Some Atherogenic Indices in Sera of Myocardial infarction, Ischemic Heart Disease Patients and Control

Abstract

Cardiovascular diseases (CVD) are the first world's leading causes of death. One of the major risk factor for the development of CVD is dyslipidemia, which involve elevated plasma levels of (TG), (TCh),   (LDL-C), (VLDL-C) and a low level of (HDL-C). Generally, the hyperlipidemias are at risk of Ischemic heart disease (IHD) and peripheral vascular disease. The strong association between the risk of Cardiovascular Artery Diseases (CAD), high levels of LDL-C and low levels of HDL-C has been well established. However enormous contributions of TG to CVD have been underestimated. Indeed high levels of TG have been associated with an increased incidence of CAD and an increased population of small dense LDL-C particles. The ratio of TG to HDL-C was proved as strong predictor of Myocardial Infarction (MI).Cardio Risk Ratio (CRR) and Atherogenic Coefficient (AC) have a good predictive value for future cardiovascular events. Atherogenic Index of Plasma (AIP), which indicated that plasma atherogenecity, was also a significant independent predicator of CAD.

This study was primarily to evaluate the serum lipid profile and to estimate the atherogenic indices (CRR, AC and AIP).

Results showed no significant changes in TCh, TG, and HDL-C levels in MI and HID, while LDL-C showed significant increases in MI and IHD, VLDL-C showed highly significant decreases in MI and IHD, compared to control

The atherogenic indices showed significant and no significant increases in MI and IHD respectively, compared to control. The risk factor according to AIP for MI is more in developing CVD than IHD.

Keywords: CVD, MI, IHD, AIP.