Sialic Acid Is A Novel Biochemical Marker In Sera Of Iraqi Endometriotic Patients .

Abstract

Sialic acids are nine carbon acidic sugars typically found as the terminal residue of cell surface sugar chains as well as on secreted glycoproteins and in the extracellular matrix. Structural diversity and unique strategic location of sialic acids (Sias) on the cells make them one of the most important molecules in life and set the challenges for sialoglycobiologist. An important facet of Sia biology is the function of Sia-binding immunoglobulin-like lectins (Siglecs), receptors that are largely expressed across the major leukocyte lineages to mediate important innate and adaptive immune functions.

A postulated autoimmune aetiology of endometriosis derives from reports on increased polyclonal B-cell activity, abnormalities in function of B and T cells, ,  high B-cell and T-cell counts, and reduced natural-killer-cell activity.Also, high serum concentrations of Igs autoantibodies . Sialic acid binding immunoglobulins (Ig)-like lectins (siglecs) belong to I-type lectin with a selective expression on the haematopoetic cell lineages. These have amazing structural diversity to recognize and interact with an array of linkage-specific sialic acids on a glycan structure express on host cells as well as pathogen. Fourteen human and nine murine siglecs have already been identified and the list is still increasing. Innate immune system is the first line of defense evolved during the years of evolution. This is responsible for controlling and clearing invading pathogens. The results of the present study indicate that Sialic acid is a novel biochemical marker related to the immune pathological alterations of endometriosis as shown in G1 and G3 . Also, the results showed the role of zoladex in alteration immune responses as shown in G2.

Keywords Sialic acid . endometriosis . immunoglobulins . autoimmune diseases.