Design, Synthesis and Acute Anti-Inflammatory Evaluation of New Non-Steroidal Anti-Inflammatory Agents Having 4-Thiazolidinone Pharmacophore

Abstract

Naproxen suffers from general side effects of NSAIDs, owing to the presence of free carboxylic group. The study was aimed to retard the adverse effects of gastrointestinal origin. New series of 4-thiozolidinones derivatives of naproxen were synthesized Va-f. The structures of synthesized compounds have been established on the basis of their spectral FT-IR and 1H NMR data. In vivo acute anti-inflammatory effects of the synthesized compounds were evaluated in rats using egg-white induced edema model of inflammation. The tested compounds and the reference drug produced significant reduction of paw edema with respect to the effect of propylene glycol 50%v/v (control group). Compounds Va-e exhibited potent anti-inflammatory effect than naproxen (50mg/kg, i.p.) at 180-240 min., while compound Vf exhibited lower anti-inflammatory effect. Keywords: Naproxen, 4-Thiazolidinone, Anti-inflammatory activity.