Simple Indirect Spectrophotometric Determination of Amoxicillin in Pharmaceutical Preparations

Abstract

A simple, rapid and sensitive indirect spectrophotometric method has been described for the determination of Amoxicillin in both pure form and pharmaceutical preparations. The method is based on the reaction of well-known oxidizing agent potassium permanganate with amoxicillin, and then disappearing of violet color of permanganate can be monitored to be proportional to the amount of amoxicilline in the pharmaceutical preparations. The optimum experimental conditions for the reaction have been studied carefully. It was observed that the proposed method has many considerable and reliable figures of merits. Beer's law is obeyed from 0.1-1.6 mg.dL^-1.  The detection limit was 0.04mg.dL^-1 and the recovery was about 98mg.dL^-1. Based on the obtained figures of merits, the proposed method is well-suited for the determination of amoxicillin in different pharmaceutical preparations and routine analysis.

Keywords: Determination, Amoxicillin, Spectrophotometry, Potassium Permanganate.