A Study of Visfatin Levels and Other Related Parameters in Sera of Iraqi Non Diabetic Male with Hyperlipidemia

Abstract

The aim of the present study is to evaluate the levels of visfatin in sera of non-diabetic male with hyperlipidemia classified according to Frederickson classification  .At the same time to find the correlation of visfatin with related parameters in the studied groups. The study included (22) healthy Iraqi male as control group (G1) and (62) non-diabetic male diagnosed with hyperlipidemia which divided into three groups as follows: group(2)consist of (20)male with hypercholesterolemia[Type I] ,group (3)consist of (20) male with hypertriglyceridemia [Type IIa] and group (4):consist of (22)male with hypercholesterolemia and hypertriglyceridemia [Type IIb] .The age of all studied groups ranged between (21-50) years and BMI with (19.8-24.3) Kg/m² .Serum was used for determination of FBG, lipid profile(HDL,LDL,VLDL,TG) ,insulin ,CRP and visfatin .Whole  blood was used for determination of  HbA1C. The results revealed  no significant elevation in FBS and HbA1C levels were seen in patients groups when comparing to healthy control . The results indicates a significant elevation in TC and LDL in G2and G4 comparing to G1. Also, there are significant elevation in G3 comparing to G 2 and G4 comparing to G3,while no significant elevation was found in TC and VLDL in G3 with G1and G4 with G2.The results ,also, illustrated significant elevation in TG and VLDL in G3 and G4 when comparing to G1, and in G3,G4 comparing to G2 . No significant elevation was noticed in G2 comparing to G1and G4 comparing to G3 . HDL levels showed significant decrease in G2,G3 and G4 comparing to G1. No significant decrease seen in G3 and G4 comparing to G2 and in G4 comparing to G3.A high significant elevation in insulin and HOMA-IR levels in G2,G3 and G4 was found when comparing with G1 , while a significant elevation  was noticed in G3 and G4 when comparing with G2 and in G4 when comparing with G3. The  results, also ,showed significant increase  in CRP  and visfatin levels for  G2,G3 ,G4 when comparing to G1  and in G4 when comparing to G2 and  G3 . But no significant elevation was found in G3 when comparing to G2 .A significant positive correlation was found between visfatin levels and TC in G1,G2 and G4 while significant negative correlation was observed in G3 between visfatin and TC. A high significant positive correlation coefficients was found between visfatin and TG in four studied groups .The results , also, showed a significant negative correlation between visfatin levels and HDL for all studied groups .The results  illustrated significant positive correlation in visfatin levels with LDL in G1 and G4 while there are significant negative correlation in visfatin levels with LDL in G2 and G3. A significant negative correlation between visfatin and insulin ,HOMA-IR levels was noticed in all studied groups.

The conclusion could be drown from this study that visfatin increased in  G4 more than other groups comparing to G1 . Also, there are significant correlation between visfatin levels with insulin , HOMA-IR and CRP levels.

Keywords : visfatin , Insulin , CRP , Hyperlipoproteinemia